ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2022 29 GLUCONEOGENESIS INHIBITION Gluconeogenesis is the major glucose-producing metabolic process in ruminants. This pathway is regulated by substrate availability and hormones such as insulin and glucagon. Insulin’s job is to inhibit gluconeogenesis and decrease glucose output when necessary. SUPPLEMENTING WITH PLANT EXTRACTS TO PROMOTE MILK PRODUCTION Milk production can be improved by promoting the “glucose sparing” effect and limiting gluconeogenesis inhibition. We started with the hypothesis that lower insulin levels could lead to a change in glucose distribution, directing more towards the mammary gland and thus improving milk production. A study was conducted to assess the effect of rumen-protected capsaicinoids (RPC) supplementation on a response to a glucose tolerance test measuring blood glucose and insulin concentration (Oh et al., 2017). Glucose concentration was not affected by RPC supplementation post glucose challenge. However, compared to the control, RPC decreased serum insulin concentration post glucose challenge. The area under the insulin concentration curve was decreased 25% by RPC (See figure 1). In this THE NEX(T) GeneraTion of funcTional addiTives NexUlin is the first feed additive for ruminants based on the innovative non-nutrition concept. It consists of a single active molecule, extracted from nature and offered exclusively by Pancosma. Through an identified mode of action, the active ingredient targets a precise pathway, to support transition and alleviate the energy deficiency during early lactation. NexUlin delivers clear opportunities to maximize your ROI and brand loyalty. www.pancosma.com Follow us on Figure 1: Effect of RPC on serum insulin concentration following intravenous administration of glucose in dairy cows
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