Feed & Additive Magazine Issue 26 March 2023

March 2023 Year: 3 - Issue: 26 Karel Vervaet, BESTMIX® Software Advantages of feed formulation software Dr. Cornelia Becker, Biochem Toxin management for dairy cows: Is it really that important? Natthanan Nukitrangsan, CP-BIO A new perspective in gut–brain axis: Pay more attention to postbiotic www.feedandadditive.com Tips for Preparing Proper Feed Formulations & Contribution of Software and Digital Technologies Technological Feed Additives: Toxin Binders, Emulsifiers, Stabilizers, Acidity Regulators & Preservatives

Technology, especially digital technology, is changing and transforming our personal and professional lives step by step. We've all experienced this one-on-one in communications, finance, retail, education, and many other fields for many years. Think about how technology has changed our communication and access opportunities, our habits and needs… What about the impact on our purchasing behaviour? There are many things we have transformed from physical habits to digital habits... I consider this new world, in which we are surrounded by digital technologies, as an unlimited quantitative and qualitative data bank. If you believe in science and agree with the idea that knowledge is power, you are also aware that this world provides you with "enormous opportunities." But how do these provide “enormous opportunities”? Let's try to explain this through the digital technologies that have become widespread in the animal nutrition industry. One of the most common digital tools in the industry is software developed for feed formulation. Most of the companies that produce feed have to make use of a feed formulation software today. Because in a highly volatile and competitive market, they are under serious pressure to produce the most nutritious feed for any animal species in the most economical way. The biggest determinant of feed costs is raw material. A raw material that is very affordable and available today may be very expensive or inaccessible tomorrow. In such a case, you may need to remove the raw material in question from the formula. It is quite difficult to manually determine both the more economical raw material to replace it and the necessary supplements to compensate for possible nutrient losses. However, digital technologies can allow you to do this very quickly, in a very short time, thanks to a database created in the light of scientific data and experience. Thanks to these technologies, you can measure your environmental footprint and identify how you can reduce it. Or you can revise it to increase your operating efficiency by comparing the data between the amount of feeding, its method and the amount, quality of animal food production. If you want to know more about this topic, this issue is for you. Valuable representatives of the industry from all over the world wrote down their experiences on both proper feed formulations and digital technologies for our readers. Hope this will be a useful issue that you will read with pleasure… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR An unlimited quantitative and qualitative data bank Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadd i t i ve Dear Readers,

Learnmore, visit www.selko.com YOUR BENEFITSWITH SELKO Specialty feed additives to optimise animal performance and customer value Unique products backed by sound science Expertise to help customers win Manufactured at highest quality standards


C O N T E N T S ARTICLES FeedKind protein wins FDA GRAS status for use in aquaculture 11 CCPA prepares animal nutrition industry for high heat with new solutions 12 ADM shares key opportunities for innovation in pet nutrition market 84 Skretting India launches state-of-the-art shrimp and fish feed facility 16 Agrimprove announces its knowledge site AllAboutToxins.com 85 Adisseo completes acquisition of Nor-Feed 77 Mosa Meat and Nutreco work together to reduce cost of cell feed 82 NEWS REPORTS EUROPE ANIMAL FEED MARKET 72 66 HELP SAFEGUARD DAIRY COWS FROM HEMORRHAGIC BOWEL SYNDROME James D. Chapman, Phibro Animal Health 68 SOLID & SCIENCE-BASED TECHNOLOGY TO OPTIMIZE FEED COSTS Dr Stéphanie Ladirat, NUQO 62 A NEW PERSPECTIVE IN GUT–BRAIN AXIS: PAY MORE ATTENTION TO POSTBIOTIC Natthanan Nukitrangsan, CP-BIO INTERVIEW GUT HEALTH, DIGESTIBILITY AND FEED CONVERSION RATIO IN POULTRY 42 Aldo Rossi & Reagan Culbertson, Amlan International

NEWS 6 FEED & ADDITIVE MAGAZINE March 2023 Evonik aims to help keep sows, laying hens and dairy cows healthy with a new plantbased product. The product, called PhytriCare® IM, consists of selected plant extracts with a high flavonoid content. Flavonoids are known for their anti-inflammatory effects. The product is available immediately throughout the EU. Approvals in other countries have been initiated. “Healthy animals are in the interest of us all,” said Dr. Gaetano Blanda, head of the Animal Nutrition business line at Evonik. “The farmer benefits from higher productivity, and the consumer can enjoy Evonik launches first plant-based feed additive Evonik launched PhytriCare® IM, the first plant-based feed additive arising from the cooperation with Dr. Eckel Animal Nutrition. According to the company, flavonoid-rich plant extracts in PhytriCare® IM alleviate inflammation in sows, laying hens and dairy cows. ADM opened more than $30 million state-of-the-art production facility in Spain to meet growing demand for probiotics, postbiotics and other products. ADM, one of the world’s leaders in science-backed nutrition solutions, announced that it opened a new production facility in Valencia, Spain to help meet rising global demand for probiotics, postbiotics and other products that support health and well-being. The production facility represents an investment worth of $30 million and a more than fivefold increase in ADM’s production capacity, increasing it to 50 metric tons per year. The facility will allow ADM to supply growing markets for probiotics and postbiotics in the U.S., Asia-Pacific and Europe. ADM expects its customer base will more than triple over the next five years as more people recognize the links between the gut microbiome and many aspects of health and look for products tailored to their specific needs. The facility, the world’s first to produce both probiotics and postbiotics at the same site, will help the company fulfill its expansion strategy in the health and well-being sector. ADM is on its way to realizing its ambition to increase health and wellness revenue from over $500 million in 2022 to $2 billion within 10 years. “Health and well-being are one of the three enduring trends powering ADM’s growth strategy: Consumers are increasingly aware of the role their gut microbiome can play in their everyday lives, and they’re seeking nutrition solutions that are backed up by science-based research,” said Mark Lotsch, president, Global Health & Wellness. “ADM is a leader in meeting this growing global demand, and we’re continuing to invest in the cutting edge of health and nutrition,” he said. Read more>> ADM opens $30m state-of-the-art production facility in Spain

NEWS FEED & ADDITIVE MAGAZINE March 2023 7 meat, eggs, or dairy products safe in the knowledge it is coming from healthy animals.” Since the prophylactic use of antibiotics has been banned in Europe, many farmers are looking for alternative solutions to keep their animals healthy and productive. In addition to probiotics, various other product classes have become established, including phytogenics. Evonik Animal Nutrition adds plant-based PhytriCare® IM to its probiotics-based Gut Health Solutions portfolio. Farm animals – like all living creatures – are exposed to a variety of stress factors and respond by activating the body’s defense mechanisms. If the stress continues at a higher level for a longer period, it can lead to chronic inflammation. As a result, animal welfare suffers. The animal then uses an increased share of its energy and nutrients for the immune system rather than for beneficial activities, such as growth and performance – sometimes for months or years. Consequently, production efficiency decreases and the animal’s ecological footprint increases. “PhytriCare® IM was developed to prevent an overshooting of inflammatory reactions in sows, laying hens and dairy cows,” added Nicholas Guthier, head of EMEA Region & Global Key Accounts at Animal Nutrition. “After all, female animals are particularly stressed by reproductive processes anyway.” Read more>> AB Vista, a company offering pioneering products and technical services to the global animal feed industry, broadened gut-health portfolio with product acquisition from biosciences company Hankkija. Progres®, purchased from the Finnish company, is a patented natural resin acids product that improves gut integrity by reducing inflammation and stimulates tissue recovery with a healing effect. It also beneficially modulates intestinal microbiota, favouring butyrate producers and lactobacilli, reducing the growth of Gram-positive pathogens. First developed in 2015, Progres improves performance in poultry, swine and ruminants, and is an important part of antibiotic-free production systems. “Progres is an exciting natural product based on a strong research and scientific background that supports a more sustainable approach to animal production, so fits well with our whole ethos at AB Vista,” said Juan Ignacio Fernández, AB Vista’s Managing Director. “Adding Progres to our portfolio expands the support we can provide nutritionists, veterinarians and production managers, looking for strategies and production programmes that deliver improved gut health, nutritional optimisation, and food safety & security. This acquisition also demonstrates our commitment to growing our offer into the wider additives market.” Read more>> AB Vista acquires Progres® natural additive from Hankkija

NEWS 8 FEED & ADDITIVE MAGAZINE March 2023 Anpario, the independent manufacturer and international distributor of natural, sustainable feed additives for animal health, nutrition and biosecurity, announced the launch of a new product range. The new products have been developed to comply with recent changes to the (EC) 1831/2003 register, formulated to be free from ammonium formate and will sit within Anpario’s well-established Acid Based Eubiotic (ABE) and Feed Hygiene ranges. Ammonium formate is most commonly associated with the production of buffered organic acids, an additive frequently utilised in livestock diets across Europe. The recent changes to the Commission Implementing Regulation (EU 2022/415) no longer permits its use in the following species; laying hens, sows, dairy ruminants, pets and non-food producing animals. “Our new range of ammonium formate free products will enable those producers impacted by the regulatory changes to have a seamless transition to an alternative product, without impacting their performance and profitability as is associated with our consistently high-quality products”, commented Richard Edwards, CEO of Anpario. Read more>> Nutreco announced that it has taken a minority stake in animal health’s most advanced microbiome biotech company, BiomEdit. The two companies recently entered into a ground-breaking, long-term strategic research and commercial partnership – the first since BiomEdit was founded – to bring livestock and aquaculture producers innovative and truly novel feed additives developed through microbiome technology. This new announcement represents a further strengthening of this partnership. “Through this investment, we are reinforcing the unique collaboration that brings together BiomEdit’s state-of-the-art microbiome discovery platform and Nutreco’s customer access and distribution capabilities,” said Fulco van Lede, Nutreco CEO. “We’re excited about its potential to help us super-charge our supply of proprietary ultra-specialty ingredients, speed up progress on our purpose of Feeding the Future and create a more sustainable future for our industry.” “Nutreco’s investment in BiomEdit underscores our strategic partnership and a shared mission to create novel animal health solutions through the untapped potential of the microbiome,” said Aaron Schacht, CEO of BiomEdit. “We are pleased that Nutreco, a global leader in animal nutrition and aquafeed, is joining our roster of world-class Series A investors to help fuel innovation in feed additive products.” Read more>> Nutreco takes minority stake in biotech company BiomEdit Anpario launches new “Ammonium Formate Free” product range


NEWS 10 FEED & ADDITIVE MAGAZINE March 2023 EU authorizes YANG for use in feed for organic production Lallemand Animal Nutrition announced that its innovative yeast solution YANG can be used in organic production in the EU under Regulation (EU) No 2018/848. With this new addition, the full Lallemand yeast portfolio can be used in feed for organic production. Nutritionists and feed millers serving the organic farming sector now have access to one of the most innovative yeast derivative products documented to help reinforce natural defenses and support gut health in all animals, including pets. “In several countries in the EU, the organic food industry has experienced a real boom in the last decades. With a wide offer of different yeast-based solutions suitable for organic production, Lallemand can help contribute to the sustainability of animal production and help to maintain animals’ welfare,” commented Monika Leukert, Yeast Derivatives & Antioxidants Product Manager. According to the company statement, YANG is a research-proven innovative feed ingredient combining inactivated yeast fractions from different and selected strains, each produced using dedicated processes. YANG is formulated to have strong bacteria-binding capacities and broad immune modulation properties while securing performance. Read more>> Nutrition Partners and FarmHouse Consultants launched Ignite – a functional fatty acid and enhanced yeast supplement designed to deliver next-level results for swine production across Canada and key regions of the US. Ignite features the latest in bio-based feed technology from CBS Bio Platforms, providing a comprehensive blend of multiple Feed Science Platforms (FSPs) for use in swine. “Ignite is a true game changer for hog operations – bringing more profits, better health and better performance,” said Patrick Hague, Founder of FarmHouse. “It’s designed first and foremost with the farmer in mind – giving them the best solution that will make a real difference to their success.” Farmers today are challenged by high feed costs, restrictions on antimicrobials and rising pressure to shift the production toolbox to natural bio-based solutions increasingly favored by the marketplace. They also face pressure to adopt new approaches to health management that are focused on prevention and upholding high standards of animal care and welfare. Ignite addresses all of these needs in one practical solution. “Ignite is the next step in the evolution of feed technology for swine – a brand new type of production-enhancing solution that fits the needs of today and the future,” said Darrell Kimmel, Sales Manager with Nutrition Partners. “It’s not only a tool that gets more efficiency and value from feed to lower the cost of production. It’s also a natural growth promoter and a next generation health management tool. It makes life easier for farmers and gets them better results. It’s also excellent for the animals – helping them maintain a high plane of health and well-being.” Read more>> Nutrition Partners and FarmHouse launch Ignite for swine

NEWS FEED & ADDITIVE MAGAZINE March 2023 11 FeedKind protein wins FDA GRAS status for use in aquaculture Bühler expands TUBO conveyor line for flexibility and efficiency Calysta, one of the world leaders in fermented protein, announced that its leading product, FeedKind®, has achieved generally recognized as safe (GRAS) status with the United States Food and Drug Administration (FDA). The FDA’s Center for Veterinary Medicine have granted Calysta’s FeedKind protein GRAS status for use in the US in salmonid feeds at up to 18% of the diet. In the US FeedKind will be listed under its common name, dried fermentation biomass. According to the company, the ruling means aquaculture companies in the US now have access to a nutritionally rich and non-GMO protein ingredient that both helps preserve biodiversity while addressing a growing market need for proteins for feed and food. “With so many exciting developments in US aquaculture, we are thrilled to be able to access this market. FeedKind protein is a perfect fit for the trout industry and the burgeoning recirculating aquaculture systems (RAS) industry for Atlantic salmon,” said Allan LeBlanc, VP and Aquaculture Lead at Calysta. “FeedKind is an exceptional alternative to other sources of protein, and is free from heavy metals, pesticides, and microplastics, ensuring animals are only fed the nutrients they need. Because it can be produced year-round using no arable land and without using any plant or animal ingredients, it truly is a protein without limits.” Read more>> Swiss technology group Bühler announced the launch of a new 8-inch TUBO tubular push conveyor. With the new solution customers in malting and brewing, milling, coffee, oat flakes, and animal feed processing industries can benefit from an increase of 80% of throughput capacity, reaching up to 43 tons per hour. “The new addition builds on the success of the revolutionary TUBO system with push technology. With the new 8-inch tubes we offer a system for an even broader range of applications with higher capacity requirements,” said Stefan Anshelm, Product Manager Grain Quality & Supply at Bühler. Up to now, the system has been available with tubes in 5-inch and 6-inch diameters with a throughput ranging from 12 tons per hour to 24 tons per hour. The new TUBO with 8-inch tubes allows for capacities of 40 to 43 tons per hour. The system transports products gently over distances of up to 50 meters in all directions. “With lighter loads and fewer bends in the system’s configuration this can be increased to 70 meters,” said Markus Huber, Product Engineer at Bühler. Like previous releases the new 8-inch TUBO follows the simple and effective principle of pushing instead of pulling. Loose pusher elements called TUBITs are pushed inside the tubular construction moving material gently from inlets to outlets. Read more>>

NEWS 12 FEED & ADDITIVE MAGAZINE March 2023 Animine scientific team participated in the “Sustainable Forages for Net-Zero in Livestock Production” meeting and presented “Evaluation of forages mineral composition with a new portable device”. According to Animine, this event, held in London, was the right moment to present Animine latest research outcomes on the calibration of the new AniGun® tool, based on the X-Ray Fluorescence technique. “One of the main limitations in precision formulation is that forages are extremely variable in mineral content and can contain antagonists that reduce the availability of some minerals (i.e. Cu, S, Mo and Fe). A quick and accurate assessment of the macro (P, Ca…) and micro-mineral (Zn, Cu, Mn…) composition in the ingredients of the ration is also extremely important to avoid nutritional imbalances, economic losses, and environmental impacts. For these reasons, Animine set the goal of providing analysis of minerals in forages with a portable device, usable on the field. For the calibration, samples of forages (grass, hay and grass silage) were collected. Forage macro and minerals mineral content was directly determined by AniGun®, and in parallel, samples were analyzed by wet chemistry technique (ICP-AES) in the INRAE lab,” Animine said in a statement. Read more>> Animine shares its latest research on calibration of AniGun tool CCPA Group, specializing in animal nutrition and health, announced that it developed the THERMO® range, nutritional solutions specific to each species, to be used in preventive or intervention, and digital solutions to anticipate and better manage the impact of high temperatures. The company drew attention to the high heat in its statement: “Earth just had the eight warmest year on record and in 2022 Europe recorded its hottest year. This climate has not been without consequences on the animals. Thus, in a single day of July in the West of France, the regional renderer Secanim collected 1 500 tonnes of poultry from 130 farms. In pigs, a decrease of 0.83 kg in slaughter weight was observed over the summer months compared to the same period in 2021. In dairy cows, the loss was estimated at 107 kg/month/ cow from June to September. The year 2023 has already started with temperature records and official bodies predict an even hotter summer than 2022. Faced with this, it is essential to set up a complete feeding and livestock management strategy to ensure their thermal comfort, support breeding performance and ensure the income of the farmer.” Read more>> CCPA prepares animal nutrition industry for high heat with new solutions

NEWS FEED & ADDITIVE MAGAZINE March 2023 13 Evonik multiplies production capacity for probiotics Evonik modernized and expanded probiotics production at its site in León, Spain, laying the foundations for further growth in the Gut Health Solutions business. The capacity for producing Ecobiol®, Fecinor® and GutCare® has been more than doubled. The León site can now produce the equivalent of 6,000 metric tons of blended final probiotic product per year. With a stronger focus on probiotic-based alternatives to antibiotic growth promoters, Evonik’s Animal Nutrition business line aims to provide solutions that ensure the well-being and performance of the animal while protecting human health and supplying a growing world population with high-quality animal protein. “Providing sustainable solutions for improving animal health and well-being is a matter close to our hearts, and at the same time a strategically important growth business for Evonik,” said Gaetano Blanda, head of Evonik’s Animal Nutrition business line. “With this expansion in León comes the ability to meet the growing demand for our probiotics product line. We will continue to demonstrate the impact of our solutions on the microbiome, gut function, and animal performance.” Probiotics are living microorganisms added to animal feed to maintain or restore the microbial balance in the animals’ intestines. “As long as there are enough ‘good’ bacteria to keep potential pathogens at bay, an animal remains healthy,” explained Torben Madsen, head of Sustainable Healthy Nutrition at Evonik Animal Nutrition. Read more>> AllAboutToxins.com Because healthy and performing animals require toxin-free feed The specialists at Agrimprove are dedicated to supporting healthy and performing animals. One of our beliefs is that understanding toxins is the first step to protecting against them. Visit AllAboutToxins.com now!

NEWS 14 FEED & ADDITIVE MAGAZINE March 2023 Alltech, a global leader in agriculture and animal nutrition, and Finnish circular-economy company Finnforel joined forces to acquire the Raisioaqua fish feed production facility from Finnish company Raisio. Raisioaqua manufactures environmentally friendly feed for aquaculture and specializes in functional feeding solutions that are suitable for northern conditions. The acquisition will complete Finnforel’s sustainable circular-economy fish-farming chain while also enhancing aquaculture producers’ access to Alltech’s nutritional technologies. “Aquaculture continues to be one of the world’s fastest-growing sources of protein, according to Alltech’s annual Agri-Food Outlook, and is one of the key focus areas for our business,” said Dr. Mark Lyons, president and CEO of Alltech. “Together with Finnforel, we will be enhancing the quality and availability of nutrition for sustainable aquaculture systems. Aqua producers will benefit from the strength of Alltech’s scientific research and commercial expertise globally, including a dedicated aqua nutrition research center, the Alltech Coppens Aqua Centre (ACAC) in the Netherlands, which specializes in nutrition for recirculating aquaculture systems (RAS).” Read more>> Alltech and Finnforel join forces for sustainable aquaculture feed production Si-Ware and Cargill partner to provide feed analysis solutions to dairy industry Si-Ware Systems, the creator of the NeoSpectra material analysis platform, announced a collaboration with Cargill Animal Nutrition to provide the NeoSpectra platform to their North American dairy teams for the on-site analysis of forages, feeds, and feed ingredients. The NeoSpectra platform uses cutting-edge spectroscopy techniques and machine learning to analyze the nutrient content of feed and feed ingredients quickly and accurately. With over 120 years of experience in animal nutrition, Cargill operates in over 40 countries to help livestock and aquaculture farmers, feed manufacturers, and distributors of all sizes deliver better animal nutrition through unparalleled research capabilities, innovative feed and premix products and services, and digital modeling and formulation solutions. Additionally, Cargill has extensive experience and expertise with Near Infrared (NIR) analysis and operates global networks of NIR analyzers to facilitate the efficient and sustainable use of feeds and feed ingredients. The announced agreement pairs Cargill’s market, research, and technical expertise in dairy farm nutrition with Si-Ware’s ground-breaking NeoSpectra platform. Read more>>


NEWS 16 FEED & ADDITIVE MAGAZINE March 2023 United Petfood, international producer of dog- and cat food, announced its intention to take a stake in Turkish manufacturer Lider Pet Food. Lider Pet Food is a pet food producer with two high-tech production facilities in Turkey. The company has 15 years of experience in the production of dry pet food for dogs and cats as well as feed for birds, rabbits and rodents. Lider also supplies wet pet food and treats for several of its own brands. “The aim of this partnership is to exchange knowledge and grow together. Lider remains fully self-managed,” according to United Petfood. Read more>> United Petfood to acquire stake in Lider Pet Food Skretting India launches state-of-the-art shrimp and fish feed facility Skretting, Nutreco’s global aquafeed division, opened a state-of-the-art production facility for shrimp and fish feed in Mangrol, Surat. The newly set up high-end facility is part of Skretting’s commitment towards the Indian aquaculture sector and its strategy to further develop in Asia. The facility was inaugurated on February 13, 2023, by Dr. Sanjeev Balyan, Hon’ble Minister of State of Fisheries, Animal Husbandry and Dairying. Michiel van Erkel, Agriculture Counsellor for India and Sri Lanka, Embassy of the Kingdom of the Netherlands was also present at the opening. Spread over an area of 20,000 sq mt and built with an investment of EUR 18.5 million, the facility will cater to both shrimp and fish cultures. The shrimp cultures will include white tiger and black tiger, while fish cultures will include Indian major carps, and high-value fish like snakehead, seabass, among others. The Mangrol facility has three production lines with a production capacity of 50,000 metric tonnes per annum. It can produce both extruded/floating and pelleted/sinking feed as per the requirement of the species and customers. There is also adequate land and infrastructure available to increase the production capacity in the future. “We are thrilled to announce the launch of our state-of-the-art production facility at Mangrol in Surat. We have been meeting the needs of shrimp hatcheries, nurseries, and farmers since 2018 in India, and supporting customers across feed-farmhealth with our high-quality feed and services. The new facility enables us to contribute our bit to the prestigious Atmanirbhar Bharat – Make in India initiative, while simultaneously improving the efficiencies for a closer connect with our customers. We will cater to the domestic market and also customers in Bangladesh, Sri Lanka and The Middle East,” said Dr. Saurabh Shekhar, General Manager – Nutreco South Asia. Read more>>

NEWS FEED & ADDITIVE MAGAZINE March 2023 17 BASF and Cargill expand their partnership to South Korea BASF and Cargill (Provimi) have expanded their partnership, adding South Korea, the first Asian nation, to their existing feed enzymes development and distribution agreement. Together, the two companies are committed to bringing innovative enzyme-based solutions to the market, generating distinctive value for animal feed customers. By combining the enzyme research and development strengths of BASF with Cargill’s know-how in application and broad market reach, the partners will form a joint innovation pipeline for animal protein producers. In fact, South Korea is the first market to launch Enzae® Manno, made with Natupulse® TS, a preparation of mannanase, produced by BASF’s new production strain Thermothelomyces thermophilus. With the expanded geographical reach, BASF and Cargill (Provimi) aim to bring the voice and commercial insights of South Korean protein producers to craft the next generation of enzymes jointly. Through this next stage of collaboration, the partners strive to deliver even more solutions that address productivity, sustainability, and cost challenges for South Korean customers. “We are honored to be the first country in our region to join the alliance with BASF and to be the first in the world to launch Enzae Manno,” said Bill So-Woong Kim, the North Asia commercial director for Cargill (Provimi) premix & nutrition business. “The collaboration will provide more of our customers with access to high-performance enzyme solutions that we have seen reduce nutrient waste, improve feed efficiency, and sustainably promote animal performance.” Read more>>


ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2023 19 Advantages of feed formulation software Karel Vervaet, BESTMIX® Software Digital technology delivers decision-making data for feed formulators Vinicius Chiappetta, Cargill Synchronized technology & services inform precise feed formulations Julien Mailliu & Guillaume Olivier, ADM Animal Nutrition Minding the gap between quality management and feed formulation Ricardo Amaral, Optimal Tecnologias Revolutionizing animal health with computer-aided phytotherapy Naveed A Chikan, Daskdan Innovations Formulating animal feed rations with a Pearson Square Megan Van Emon, Montana State University

ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE March 2023 ADVANTAGES OF FEED FORMULATION SOFTWARE “As a feed producing company the volumes to process, the legislation imposed and the time pressure to get feed to the market are so high you cannot do this without an appropriate tool. The fact that we deliver our software already close to 50 years to the industry is only more proof that the feed industry saw the need to digitize their data and processes.” BESTMIX® Software, formerly known as Adifo, is a company that develops a unique range of software tools specific to the food and feed industry. The software tools in the company's portfolio focus on topics such as the least-cost recipe formulation, quality data management, ration calculation, cloud services and ERP. BESTMIX® Recipe Management, one of the company's most important software, is widely used in the feed industry. Karel Vervaet, Senior Product Specialist of BESTMIX® Software, which has half a century of experience in its field, explained both the importance of the software in feed production and what the BESTMIX® Recipe Management software provides to users. Mr. Vervaet, can we say that software simply means collecting data, storing, analyzing and strategizing according to the analysis? If so, why is data important? Can you explain the importance of data in the feed production sector? No, I think software cannot be labeled like that. For sure software exists out there that fits the description, but if I look at our software, then of course the data is key, but the features you apply on the data, the representation of the input and output, the user experience you give to users when working with the software are equally important as the data itself. Correct information / data is important in any industry, also in feed production. Some of the data can be collected in an automated way, like for instance animal performance figures on farm. Other data needs to be managed by knowledgeable users, to allow to generate the desired output. A perfect example for this are for instance the requirements that will determine the outcome of a least cost formulation. Today's world is very changeable. For example, while any feed ingredient may be abundant and cost-effective one day, it may be the opposite another day, or a highly preferred ingredient today may be replaced by a new alternative tomorrow. How do such changes affect the feed industry and can software help keep pace with these changes quickly? How? The topic raised here is the day-to-day reality for our customers, and the feed industry as whole. The logistical challenge they face is to get the right raw materials Karel Vervaet Sr. Product Specialist BESTMIX® Software

ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2023 21 sources at the right moment at the right production location. With the help of our software, you can: • Make sure you have all the available input from ERP available in the formulation system (production forecast, current market prices, future market prices, contracted amounts with their prices etc) • Run simulations in BESTMIX® Recipe Management that will calculate which amounts to buy, when to buy them, and for which production location, and share this information again with the ERP system so the purchase department can take the appropriate actions • Anticipate and prevent that big fluctuations in either quality or price have a too big impact on the feed being produced and delivered on farm Another issue is the change of priorities. Due to the increasing competitive environment, cost-effective production is extremely important. On the other hand, factors such as sustainability and environmental impact are intensely on the agenda today. Can you tell us what the software offers to feed producers at the point of providing all these together? Sustainability is ‘the’ talk of the industry at the moment. The pressure to be more sustainable is very high, both from the government, but also from the consumer side. When looking at sustainability you have to consider the entire value chain, so not only producing feed in a more sustainable way, but also consider what happens on farm, in the slaughterhouse, right up to the retail. Furthermore, it is also important to not only look at the carbon footprint, because also in the animal production this only represents a small peace of the total impact. Another important topic here is objectiveness or certification. You need to be able to guarantee when you calculate the environmental footprint, that there is a way consumers can validate the outcome. Therefore, we partner with experts in the industry. BESTMIX® Recipe Management itself does not have the capability to calculate the environmental footprint, but our partners do, and we display the result during the formulation of a recipe or a feeding program. As a user you then have the opportunity to deep dive into the sustainability figures. In our latest release we also added optimization on environmental footprint to the software. Since this will impose extra constraints on the price, you have the ability to define what price increase you allow to realize a better environmental footprint. What is the usage rate and prevalence of software and digital technologies in the feed industry? Can you share your general impressions on this subject, especially in the regions you serve? In the regions we serve, everybody works with software. As a feed producing company the volumes to

ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE March 2023 process, the legislation imposed and the time pressure to get feed to the market are so high you cannot do this without an appropriate tool. The fact that we deliver our software already close to 50 years to the industry is only more proof that the feed industry saw the need to digitize their data and processes. Let's go back to the software solutions you offer to the feed industry. Can you tell us about your Bestmix software and its features? What does this software offer to feed producers or animal breeders who produce their own feed? Benefits BESTMIX® Recipe Management has to offer: • 01 / Cost reduction BESTMIX® Recipe Management takes into account the impact of the production process on the nutritional and functional properties of your ingredients. By estimating the effect of enzymes and drying, amongst other things, in advance, you can easily and quickly formulate the most cost-efficient recipes. • 02 / A flexible switch The raw material and feed market is constantly evolving. BESTMIX® Recipe Management allows you to adapt quickly. In case of fluctuating raw material prices, changing logistic challenges or new regulations, our software will give you a quick insight into the appropriate alternatives. Moreover, this knowledge proves its value while advising your customers. They learn in detail how fluctuating animal and raw material prices affect their results and how they can anticipate this with your help. Your customer advisor quickly learns to know the specific expectations of the end users and feed them back to the formulator via BESTMIX® Recipe Management. • 03 / The controlled creation of labels and specifications After the creation or optimization of a product, BESTMIX® Recipe Management will automatically adapt the required legal and commercial documents. All labels, product specifications, feeding tables and safety datasheets will be immediately available, both inside and outside the company walls. • 04 / A streamlined collaboration within a secure environment BESTMIX® Recipe Management facilitates the internal collaboration between nutritionists, formulators, R&D, quality employees, purchasers, production employees and customer advisors. The inventive central platform also allows to safely exchange information in real time with external parties such as laboratories, consultancy companies and auditors. • 05 / Save time BESTMIX® Recipe Management accelerates the development time of new recipes, allowing you to introduce more quickly new or adapted products to the market. With a centralized database, both feed

ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2023 23 advisors and formulators cooperate during the creation of rations and complete feed, allowing you to avoid repetitive work. • 06 / Future-oriented BESTMIX® Software has developed BESTMIX® Recipe Management specifically for the nutrition industry. Thanks to continuous updates, based on the latest developments within the sector and the feedback from our customers, our software always follows the most recent market evolutions. Consequently, you will always be assured of a future-oriented formulation platform which seamlessly connects with the digital transition being developed within the nutritional world. • 07 / Always compliant Thanks to our integrated best practices, regular updates, and the possibility to integrate your own procedures, you can always work according to legal and company-specific rules. This way, BESTMIX® Recipe Management supports your company in complying with the rules; now and in the future. • 08 / Justified purchasing decisions Thanks to BESTMIX® Recipe Management, the purchase department always have detailed and up-todate information. By means of ‘What if?’ scenarios, they can simulate the effect of certain raw materials on the composition, nutritional value, and price of the end product. Therefore, they can always make their purchasing decisions in line with the reality and trends on the worldwide and local raw material markets. • 09 / A user-friendly and customizable interface BESTMIX® Software knows its users. This has resulted in an extremely user-friendly interface with many options for setting your own preferences and needs. Like most things, software is also constantly changing and updating. Could you tell us about the latest innovations in your software? Are there any special topics or features that you will present to users in the coming days or years, which are currently in progress? At BESTMIX® Software we have a great team of over 30 people working hard every day to bring innovations to the market. We stay on top of all trends and follow up with customers and partners to improve every day. Some of the features we have been working on the last couple of months are: • Ration calculation per individual cow: to allow feed advisors to give tailor-made advise to their customers. Animal performance figures are pushed to BESTMIX® Recipe Management online, so we can use these figures to calculate the optimal ration to be fed, per individual animal • As mentioned earlier, a very important feature is the use of environmental parameters in the optimization feed or feeding programs, besides the normal least cost formulation • Blend optimization - A new feature in our Multiblend option to allow you to optimize and define the perfect premix/preblend/half fabricate that will serve several main recipes. • Target optimization – in the regular least cost formulation tools, constraints on nutrient values are entered via minima and maxima. Via target optimization this is no longer required since you only need to enter the required output, and BESTMIX® Recipe Management will try to get as close as possible to these target values. • We recently also launched a new product to the market, BESTMIX® SpecTrack. BESTMIX® SpecTrack centralizes data of your suppliers on one single web platform. Our solution supports you in enforcing compliance and collecting information from suppliers. The ever-increasing demands of retailers, legislation, auditors, and management require a more structured and efficient approach. As a manufacturer, you manage digitally structured information of your needs in the field of product composition, allergens, nutritional values, certificates, assessments, and more. Consequently, by using BESTMIX® SpecTrack, you always dispose of one version of the truth. Information is efficiently shared with product developers, quality assurance staff, production managers and other stakeholders. BESTMIX® SpecTrack meets the demand for transparency, traceability, and quality assurance

ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE March 2023 within the food, petfood and animal feed industry. Moreover, this platform integrates with your recipe formulation, which contributes to efficiency and flexibility in your organization What do you think is an efficient and proper feed formulation? What should be paid attention to when choosing and using a software for this? When looking for software in general I think some aspects are important: • Technology used • Customer service availability (phone, online, FAQ, …) • References in the same industry • Local presence of the vendor • Knowledge level of the software vendor • Innovations and update delivered by the vendor on the software • Languages in which the software is available • Protection of the data entered in the system • Backup / disaster recovery in case something goes wrong • Ultimately of course also the pricing will be an aspect to consider, although in my opinion not the most important one. More important is to have a close look at the ROI of the investment • User experience, ease of use • Is the software scalable, meaning if you grow as a company, is the software and hardware setup capable of following the same growth • Flexible reporting capabilities For feed formulation software more specific I think following aspects could be of importance: • Security/authorization: who can access certain data • Performance of certain workflows, how efficient can you manage recipes • Integrated labeling solution • Ability to formulate big amounts of recipes at the same time (several thousands in some cases) to be able to do the what if scenarios as mentioned higher in the doc • Strong integration with other software (MES, quality systems, ERP, …) • When applicable, combine ration calculation, feed optimization, premix formulation in one tool • Advanced formulation techniques available: - Work with enzymes - Integer optimization - Non-linear optimization - …. We are talking about many advantages of software. But can anyone use the software developed for feed formulation, etc.? Does it require special expertise to use them? Based on your own software solutions, can we also touch on the simple interface and ease of use? I think anybody can work with feed formulation software. Of course, you will need the proper training and guidance to be able to complete your daily work. Depending on your role in the company you will need specific knowledge. Needless to say that if you do not have nutritional knowledge it will be hard to manage recipes in a correct way. The software should be designed in such a way, that any user, with limited effort can truly experience al the benefits of our tools. About Karel Vervaet Karel got his master's degree in Bioscience Engineering at the Ghent University in 1997. At BESTMIX software, he has been active for many years as a senior consultant in feed formulation software and as leader of the BESTMIX® development team. In his current position as Sr. Product Specialist Nutrition he keeps close track of the IT developments within the nutrition industry and works in close collaboration with major players in feed and petfood production. Given his experience as consultant for many international feed companies, Karel is in a perfect position to look at the role of BESTMIX® in feed manufacturing organizations and to its integration with other software. Karel has a special interest in sustainability and in how to include the environmental impact of animal nutrition production in feed formulation software.

ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2023 25 “ BESTMIX® is the only software supplier worldwide that offers solutions throughout the entire production and supply chain for feed producers: Purchase decision support, quality control, logistics and financials, sustainability concerns. • • • • “BESTMIX is a game changer. Frommultilevel formulation which allows you to optimize textured feeds, rework formulas, or formulas with postpellet fat application simultaneously to exogenous enzyme matrix application that accounts for other enzymes and their uplifts in the diet, no other formulation software comes close” - Curran Gehring, Ph.D., Nutritionist at Tucker Milling LLC www.bestmix.com With our BESTMIX feed software solution you can: Avoid production interruptions caused by unavailable raw materials Allocate raw materials at the right time to the right place and at the right price Apply enzyme functionality, integer constraints and moisture control and optimize their effects on individual recipes or ingredients to maximize profits Take corrective actions based on tangible sample data

ISSUE FOCUS 26 FEED & ADDITIVE MAGAZINE March 2023 “Technology can help determine the best formulation by helping you understand ingredient nutrient levels as they arrive at the feed mill and how to change and adapt the formulation based on how the nutrient levels change.” As new consumer demands and regulations arise, feed formulation complexity increases, as does the need to better optimize the cost of feed. In addition, animal welfare and sustainability variables must be considered in the formulation process. To make the best decisions, the use of digital solutions is key. Still, it may seem like too many digital technologies to wade through to deploy confidently for feed formulation. Technology can help determine the best formulation by helping you understand ingredient nutrient levels as they arrive at the feed mill and how to change and adapt the formulation based on how the nutrient levels change. Technology can help you use this data to select the best and most reliable suppliers to deliver the precise formulation needed for animals. But before tech deployment, you must be mindful of your overall strategy. Look at how you reach your customers, consider the ingredient market, and explore all the scenarios available to optimize margins. In some cases, a formulation might be more expensive, but this will drive more results and profitability. Or you may need to build a diet that has less carbon output. Whatever digital solution you deploy should align with that strategy. Here are some technologies helpful for feed formulation: Digitalized mycotoxin data: Tap into a large dataset tied to species, region, and ingredient to solving one of our industry's biggest ongoing systemic threats. You can access a comprehensive report for free taken from more than 300,000 data points through Cargill's world mycotoxin report. Near-infrared technology (NIR): Use NIR to precisely estimate and analyze the nutritional levels of different animal feed ingredients to formulate diets more precisely. Today NIR is available through benchtop NIRs, handheld NIRs and inline NIRs. In addition, NIR analytics and mathematical modeling advancements are now connected to the NIR instruments to measure nutrient digestibility, a better predictor of nutrient availability that supports faster and more efficient growth. Precision nutrition platforms: Get real-time, accurate data that uses extensive research and development expertise. This data supports mathematical models to precisely calculate nutrient levels of ingredients beyond traditional NIR analysis for more precise nutritional design and formulation. These DIGITAL TECHNOLOGY DELIVERS DECISION-MAKING DATA FOR FEED FORMULATORS Vinicius Chiappetta Global Digital Commercial Director Cargill