Feed & Additive Magazine Issue 17 June 2022

June 2022 Year: 2 - Issue: 17 Dr. Gwendolyn Jones, ADM - Pancosma Animal science turns to advancing resilience for heat tolerance Dr. Manfred Pietsch, JRS Germany Insoluble fiber - An essential nutrient for poultry Aaron Cowieson, DSM Managing feed cost with exogenous enzymes in a volatile market www.feedandadditive.com Use of Fiber Concentrates in Animal Nutrition Heat Stress in Animals and Ways to Struggle

Dear readers, According to the report entitled “Global Warming of 1.5 ºC” published in 2018 by the Intergovernmental Panel on Climate Change (IPCC) of the United Nations, global warming possibly will reach 1.5 ºC between 2030 and 2052 if the current trend continues. This situation due to human activities for industrial purposes means that extreme weather events that have been rare to date will become more frequent. In the report, it is emphasized that extremely hot weather, which is experienced once in 50 years, is now likely to occur once in a year. This climatic change, which the IPCC reveals in its report and which we feel more and more day by day, poses a threat to all living species on earth in many aspects. For example; with increasing drought, crop yields decrease and the supply of basic food/nutritional raw materials for both humans and animals becomes more difficult. The supply of raw materials is the biggest factor in the increase in feed prices, which we have experienced very often in recent years. Added to this is the stress factor that extremely hot or extremely cold weather creates on farm animals. These stress factors, which significantly affect the animal's feed intake and performance, disrupt farm productivity and lead to a decline in animal food production such as meat, milk and eggs. However, rapidly growing world population needs increasing production, not decreasing production. So, what should be done? Putting aside the search for ways to limit carbon emissions we release into the atmosphere, it is useful to look at what can be done to protect the performance of animals in extremely hot and cold environments. In this month’s issue of our magazine, we focused on this topic and tried to include ways to alleviate heat stress on farm animals and maintain productivity. We hope that the articles prepared by expert industry representatives on the subject will guide the producers in this hot summer period. In the meantime, probably due to the fact that heat stress and loss of productivity in animals have been experienced intensely because of increasing average air temperatures; we encountered a very intense content sharing from our contributors for our issue focus. That's why we had to continue covering heat stress topic and leave some of our content to July 2022 issue. Enjoy your reading… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors James Watson Bahadır Büyükkılıç [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Branch: Ste B69, East Rutherford, New Jersey 07073, USA Publication Type: Periodic (Monthly) EDITOR How to reduce the impact of rising temperatures? Derya YILDIZ All copyrights belong to Three Plus Media.© May not be used without permission. Responsibility of the ads belongs to the advertisers. feedandadd i t i ve

*: «Doing Good » means doing the right thing for the environment and «Doing Well» means doing the right thing for the business. If not us, who? If not now, when? WE MAKE IT POSSIBLE Follow us on: Visit us at: dsm.com/anh ProAct offers infinite opportunities for your stock In its 10 years of existence, DSM superior Protease technology has led the way in Protein nutrition and sustainability, delivering impressive results globally. Offering the best results, with ProAct you do not need to choose between «Doing Good» and «Doing Well»*. So, if you want to build a brighter future for your animal business, change to ProAct and benefit from its success. To better understand how ProAct could positively support your feed formulations, please visit the following link and use the ProAct Matrix calculator: http://ronozymeproact.dsmcampus.com/

C O N T E N T S 22 ISSUE FOCUS 29 HEAT STRESS MANAGEMENT: THE IMPORTANCE OF BEEF CATTLE NUTRITION Bruno Martin, Ruminant Technical Support, Lallemand Animal Nutrition 24 MANAGING HEAT STRESS, AND A RESEARCH POSTCARD FROM DOWN UNDER Dr. Narendra Venkatareddy, Global Product Manager, Selko Feed Additives - Trouw Nutrition 34 ANIMAL SCIENCE TURNS TO ADVANCING RESILIENCE FOR HEAT TOLERANCE Dr. Gwendolyn Jones, Product Manager, Gut Agility Activators – Anco FIT, ADM - Pancosma 38 UNDERSTANDING HEAT STRESS IN DAIRY TO ALLEVIATE IT Delphine Lacombe, Global Technical Manager Ruminant, Delacon Biotechnik GmbH 42 PREPARING POULTRY FOR HEATWAVES Paulina Abramowicz-Pindor, PhD, Department of Research and Development, AdiFeed Co Ltd. 46 REDUCING HEAT STRESS IMPACT TO IMPROVE BROILERS’ PERFORMANCE... Dr. Ruth Raspoet, Poultry R&D Manager & Lin Wang, Global Poultry Program Manager, Phileo by Lesaffre HEAT STRESS IN ANIMALS AND WAYS TO STRUGGLE SPECIAL STORY 55 INSOLUBLE FIBER - AN ESSENTIAL NUTRIENT FOR POULTRY Dr. Manfred Pietsch, Head of Animal Nutrition Department, JRS Germany 60 FIBRE IN MONOGASTRIC: FROM UNDESIRABLE TO BENEFICIAL NUTRIENT Xavière Rousseau, Global Poultry Technical Manager, AB Vista Use of Fiber Concentrates in Animal Nutrition

C O N T E N T S More eggs per hen with natural oregano essential 82 Arla inaugurates its biggest dairy investment 80 Cargill to build new soybean processing facility in Missouri 79 Poultry industry reps gather together at Biochem's event in Turkey 18 Alltech ONE Conference hosts nearly 2,000 international delegates in person 11 Nanolike opens first Canadian office in Montreal 87 SalMar merges with Norway Royal Salmon 89 Novus International launches Scale Up™ program 91 ARTICLES 64 CHOLINE IS ESSENTIAL AND REQUIRED FOR EVERYBODY Stefano Vandoni, PhD, Technical Service Manager, Balchem ANH, EMEA 68 MANAGING FEED COST WITH EXOGENOUS ENZYMES IN A VOLATILE MARKET Aaron Cowieson, Corporate Science Fellow, DSM REPORTS GLOBAL FEED ANTIOXIDANTS MARKET 72 NEWS INTERVIEW 50 A success story in PoultryStar® Hatchery: ANTIBIOTIC-FREE AND HEALTHY CHICKS Irfan Coban General Manager, Biokey Gıda, Tarım ve Hayvancılık Ltd. Şti.

NEWS 6 FEED & ADDITIVE MAGAZINE June 2022 ADM, a global leader in animal nutrition, announced the acquisition of a feed mill in Polomolok, South Cotabato, from South Sunrays Milling Corporation. The addition is a step forward in providing a wide range of leading-edge products to meet Asia’s demand for innovative and high-quality products in the animal nutrition market. “Around the globe, ADM is expanding its ability to meet growing customer demand for high-quality, responsibly-produced animal nutrition products, and we look forward to bringing our expertise and production capabilities closer to even more customers in the Philippines,” said Gerald Wilflingseder, President, Animal Nutrition, Asia Pacific, at ADM. “This addition increases our regional production capacity, enabling us to enhance our wide range of leading-edge solutions to better support our customers’ dynamic needs in a timely manner, while providing further opportunities to offer new product solutions ADM expands Philippines animal nutrition footprint ADM has purchased a feed mill in Philippines from South Sunrays Milling Corporation, expanding its reach in Asia Pacific region’s animal nutrition market. Adisseo and Entobel have agreed to initiate an R&D collaboration to better understand and enhance insect rearing performance and the nutritional requirement of insects (BSF, Black Soldier Fly). Adisseo and Entobel have decided to enter into a collaboration to join their respective expertise and work on different axis. By evaluating the interest and adaptation of the existing solutions; the companies aim to improve production of insect’s meal, focused on the performance of the insects and the quality of this protein meal, prioritizing the way to control the ingredients used to feed insects, and their complementarities with the most important feed additives, like methionine and enzymes. Currently, the higher requirement of sustainable proteins sources for feed and food, in a finite world boundary; insects are a promising nutritional alternative since they are an excellent bio-converter of waste and co-products inedible for human or livestock. The success of insect production and its adoption by customers will be depending on its competitivity, volume availability and its quality over time. For that, there is a need for transformation in the rearing process based on optimal insect’s growth performance and producing a meal and oil with good nutritional value, whatever the type and quality of the raw material needed to feed insects. Normally as a natural bio-converter, insects can use all type of substrate to grow, with different FCR and mortality. This variability of substrates will require specific knowledge and a different combination of additives. Adisseo, Entobel join forces on alternative insect protein development

NEWS FEED & ADDITIVE MAGAZINE June 2022 7 in the Philippines and across the region.” The South Cotabato mill, along with existing ADM feed production facilities in Cebu and Bulacan, support customer growth in the region with a wide range of leading-edge pet food, complete feed, aquaculture, and premix solutions. Further, the investment will support economic development through the creation of more than 100 new jobs in the region. “We are excited to combine our global expertise with deep local insights to unlock greater value for our customers in the Philippines and across the region,” said Lorenzo Mapua, Managing Director, Animal Nutrition, Philippines, at ADM. “This acquisition will allow us to offer a wide range of high-quality feed products for swine, poultry and aqua for both backyard and commercial farm segments with our recognized brands such as Ultrapak, Evialis and Ocialis.” Bühler opens Insect Technology Center Bühler Group officially opened its world-class Insect Technology Center (ITC) in Uzwil, Switzerland. Bühler Group has officially opened its world-class Insect Technology Center (ITC). Located in Uzwil, Switzerland, the facility brings together Bühler’s expertise and the best infrastructure to help the industry to further develop. In the ITC, Bühler and its customers can conduct larvae growth trials with various feedstock, develop product samples, evaluate breed solutions and run trainings. The ITC, which obtained funding from Switzerland’s Federal Office for the Environment (FOEN) due to its contribution to a more sustainable food system, is already in operation. At the heart of the Center, there are two insect growth chambers that can mimic industrial production conditions. These chambers have a sophisticated climate control system and are equipped with numerous sensors that give valuable process insights. Based on the collected data, the right parameters and practices can be determined to finally ensure an efficient insect production at industrial scale. At the ITC, it is possible to work with the two most relevant insect species for industrial production, namely black soldier flies and mealworms. The ITC aims to accelerate large-scale insect plant initiatives. By using the new test facility, customers might not need to invest into expensive pilot plants to demonstrate technological feasibility. Since the insect growth chambers are mobile, they can be sent to any location, thus making the infrastructure accessible to customers worldwide.

NEWS 8 FEED & ADDITIVE MAGAZINE June 2022 Deep Branch and BioMar have signed a long-term strategic partnership to improve the aquaculture industry’s efficiency, profitability and sustainability. Deep Branch, BioMar agree strategic partnership Deep Branch and BioMar have signed a longterm technical and commercial partnership to redefine traditional aquaculture feed ingredients and improve the aquaculture industry’s efficiency, profitability and sustainability. The immediate focus of the cooperation will be to optimise salmon feed using Proton™, a single cell protein developed by Deep Branch for the feed industry, as a primary protein source. “The world needs to move from making pledges to taking action, and we are passionate about industrial ecology underpinning the next generation of food production. We see BioMar as a key partner in bringing Proton™ to market as its ambitious targets and commitment to collaboration fully align with ours,” said Pete Rowe, CEO Deep Branch. “At BioMar, we’re constantly seeking innovative raw materials that don’t compete with human food production and using nutrients from by-products that minimise waste. So we’re excited to have established this strategic partnership with Deep Branch,” said Paddy Campbell, VP Salmon, BioMar. To kick off the partnership, Deep Branch will transport Proton™ from its facility in the Netherlands to BioMar’s Technology Centre in Denmark to produce Proton™-based feed until the end of 2022. Darling Ingredients to acquire FASA Group for $560 million Darling Ingredients Inc., the world's leading company turning food waste into sustainable products and producer of renewable energy, announced it has entered into a definitive agreement to purchase Brazil's largest independent rendering company, FASA Group for approximately R$2.8 billion Brazilian Real in cash ($560 million USD at today's exchange rate). The transaction is subject to post-closing adjustments and a contingent payment based on future earnings growth. FASA Group processes more than 1.3 million metric tons annually through 14 rendering plants with an additional two plants under construction, and has approximately 2,400 employees. “Brazil is a leader in global agricultural commodities growth and is expected to take on a bigger role in world's meat production, making it a premier location for rendering growth,” said Randall C. Stuewe, Chairman and Chief Executive Officer, Darling Ingredients. “FASA will also supplement Darling Ingredient's global supply of waste fats, making it a leader in the supply of low carbon waste fats and oils in North and South America to be used in the production of renewable diesel,” Stuewe added. The transaction is subject to customary closing conditions, and is expected to close by the end of 2022. Darling Ingredients has entered into a definitive agreement to purchase FASA Group, Brazil’s largest independent rendering company, for around $560 million in cash.


NEWS 10 FEED & ADDITIVE MAGAZINE June 2022 Probiotics can help reduce use of antibiotics A peer reviewed article by University of Bologna establishes bacillus-based probiotics as a promising strategy to help tackle the increasing problem of antibiotic resistance, while also reducing the incidence of post-weaning diarrhea in pigs by 30% and mortality in broilers by 6–8%. The article, “Bacillus spp. Probiotic Strains as a Potential Tool for Limiting the Use of Antibiotics and Improving the Growth and Health of Pigs and Chickens”, confirms the positive effects of probiotics, also known as direct fed microbials (DFM), in young pigs and broilers. These special microbes demonstrate a broad array of modes of action, including direct and indirect inhibition of potentially harmful organisms. The scientific findings support the global recognition of the need to reduce the use of antibiotics in livestock production, as antibiotic resistance is rising to dangerously high levels in all parts of the world. The new review includes potential modes of action, and the effects on the performance and health of pigs (weaned piglets, lactating and gestating sows) and broilers. “Basically, this thorough review confirms the power of good bacteria,” states Kim Muller Christensen, Senior Vice President, Animal & Plant Health, Chr. Hansen, underlining that it includes several strains and products and not only those offered by the global bioscience leader itself. A just published review of 131 scientific articles evaluates the effectiveness of Bacillus strains as probiotics, and as a potential strategy for reducing the use of antibiotics in monogastric animals. FEFAC estimates that industrial compound feed production in the EU will reduce by 4–5 million tons in 2022, mostly because of the spread of animal diseases and the continuing global grain market rally fuelled by the Russian invasion of Ukraine. The European Compound Feed Manufacturers’ Federation (FEFAC) released its estimates for industrial compound feed production in the European Union (EU) for 2021 and outlook for 2022. The EU compound feed production (EU27) for farmed animals in 2021 is estimated at 150,2 million tons, an increase of 0.03 % compared to 2020, according to data provided by FEFAC members. Except for the pig feed sector, all other sectors managed to stabilize/or slightly increase their production despite the continuing COVID-19 pandemic, global grain market rally, supply chain disruptions and spread of animal diseases in 2021. Following the 2021 EU critical pig meat situation, facing challenges of reduced meat demand in key export markets (sanitary import ban & Asia-Pacific’s recovery from ASF), high costs for feed grains, the impact of African Swine Fever and significantly increased 2020 production, the pig feed production decreased by -1.5% in 2021. The countries most affected were particularly Germany, France, Portugal, Spain, Austria, Slovenia and Hungary. The Netherlands and Belgium have continued depopulation of their pig herds in order to lower agricultural environmental emissions. Looking at the market outlook for 2022, the EU pig and poultry sector are expected to reduce their EU compound feed production expected to reduce by 4-5m tons in 2022

NEWS FEED & ADDITIVE MAGAZINE June 2022 11 activities due to the high cost of feed materials, lower market demand and expanding Avian Influenza outbreaks in several countries. Hence, FEFAC members’ estimates decrease by – 4.2% for pig feed and – 3% for poultry feed. The cattle feed production is expected to decrease by – 1.6%. Overall, the industrial compound feed production is estimated to decrease by – 2.9% (i.e. 4.3 million tonnes) compared to 2021. However, market uncertainties remain very high due to ongoing Russian aggression in Ukraine. The immediate loss of feed maize, sunflower meal and other feed materials from Ukraine and Russia could only be partially compensated by increased feed imports, mainly from the US and Canada. Key logistical challenges are persisting on how to move existing grain stocks out of Ukraine and will continue to impact market availability in the new Marketing Year. The Alltech ONE Conference welcomed nearly 2,000 international delegates in Lexington, Kentucky, USA from May 22-24, 2022, with an additional 5,000 participating virtually. The Alltech ONE Conference (ONE) closed after a robust agenda of in-person and virtual activities and presentations. After being held as a virtual-only event for two years, this year’s conference, welcomed nearly 2,000 international delegates in person to downtown Lexington, Kentucky with an additional 5,000 participating virtually. In its 38th year, this world-class event brought inspiring keynote speakers and more than 100 industry leaders to the stage, sharing valuable insights in live workshops and focus tracks and uncovering the challenges and opportunities in agriculture, business, health and wellness, and professional development. “We must unify and take action, today, for the future of agriculture and our planet,” said Dr. Mark Lyons, president and CEO of Alltech in the closing session. “Together, we have the collective courage and impact to work together for a Planet of Plenty™.” Lyons was joined on the ONE Mainstage for the closing session by Mick Ebeling, founder and CEO of Not Impossible Labs, and world-class blind adventurer Erik Weihenmayer. Lyons presented the Alltech Humanitarian Award, an award that is bestowed annually to someone of strong character who uses their platform to positively influence and inspire those around them, to both Ebeling and Weihenmayer. “We are pleased to present friends and first-time double Alltech Humanitarian Awards to Mick Ebeling and Erik Weihenmayer at the Alltech ONE Conference,” said Lyons. Previous award winners have included Muhammad Ali, Steve Wozniak, Bear Grylls and late Alltech founder and Mark’s father, Dr. Pearse Lyons. Alltech ONE Conference hosts nearly 2,000 international delegates in person

NEWS 12 FEED & ADDITIVE MAGAZINE June 2022 Phileo by Lesaffre announced that the upcoming Phileo Microbiota Days will take place on June, 14–15, 2022. This virtual conference will provide an overview of the latest scientific results and future developments related to microbiota and their importance to animal health across the lifespan of different animal species. High level keynote speeches will be given by scientists from academia, institutes, and industry from Europe, the USA and Brazil. Conference topics include, but are not limited to, interactions between the microbiota and the host, relationship between microbiota and performances, biomarkers, food safety, functional metagenomics, the rumen microbiome, intestinal bacteriophages, and in vitro tools to study the microbiome. Speakers of the event include Ségolène Lebrun - GD Biotech, Laurent Debarbieux, PhD - Institut Pasteur, Prof. Richard Ducatelle - Ghent University, Dr. Lisa Williams - Hartpury University, Fanny Calenge - INRAE, MetaGenoPolis, Dr. Andres Gomes - University of Minnesota, Dr. Alex Bach-Marlex, Breno Beirao, PhD, DVM - Federal University of Paraná, Prof. SW Kim - North Carolina State University, Dr. Loc Tran - ShrimpVet Vietnam, Dr. T.G. Nagaraja - University of Kansas, Dr. Diana Luise - University of Bologna, Dr. Ruben Props - Kytos Belgium, Prof. T.R. Callaway - University of Georgia, Dr. Florian Plaza-Onate - INRAE MetaGenoPolis and Prof. Jan Suchodolski - Texas A&M University. The speeches will be followed by Lesaffre & Phileo experts, who will elaborate further on microbiota species -specific topics including ruminants, poultry, swine, aquaculture and pets. Phileo Microbiota Days to be held on June 14-15 FRAmelco to become Adisseo NL FRAmelco Group has announced that it will officially change its name from FRAmelco B.V. to Adisseo NL B.V. In December 2020, the FRAnklin Group (FRAmelco, Sustainable Nutrition, FRAnklin Asia) was acquired by the Bluestar Adisseo Company. For almost one and a half years, the FRAnklin Group, then a family owned multinational group headquartered in The Netherlands, has been working on a plan to integrate into the Adisseo family. “The first step is to announce a formal name change from FRAmelco B.V. to Adisseo NL B.V., which will take place on September 1st, 2022,” said Peter Zondervan, Managing Director of FRAmelco. “As simple as a name change might seem, a lot of processes will be influenced by it. A big impact is seen on product registrations, which need to be changed to the new name. Also, the organization of transport documents with the correct name during the moment of the actual change. We are doing our utmost to plan all activities in the correct order and within the time frame,” Zondervan added. FRAmelco Group operates 3 plants located in The Netherlands, Spain and Thailand. Netherlands-based FRAmelco Group, which was acquired by Bluestar Adisseo Company in December 2020, will officially change its name to Adisseo NL as of September 1st, 2022.

NEWS FEED & ADDITIVE MAGAZINE June 2022 13 Papillon Agricultural Company’s bypass protein products for dairy feed will soon be available in the Pacific Northwest, after partnering with Scoular on manufacturing. Papillon, Scoular partner on bypass protein products for dairy feed Dairy farmers in the Pacific Northwest will soon have access to Papillon Agricultural Company’s bypass protein products, thanks to the company’s new manufacturing relationship with Scoular. Scoular has expanded its existing feed blend facility in Jerome and in June will begin producing the proteins for Papillon. Papillon, a Maryland-based company, currently manufactures bypass protein products in New York, Indiana and Wisconsin and is now expanding to the Pacific Northwest. Papillon partnered with Scoular because of its manufacturing expertise and knowledge of the local dairy and feed markets. Papillon’s protein blends provide concentrated, highly digestible bypass protein and meet the demand for balanced amino acids in dairy diets. This allows for ration optimization to drive production or reduce costs. The products will be available to Scoular customers and regional feed manufacturers for inclusion in feed mixes for dairy. Cory Doggett has recently joined Papillon as Northwest Regional Sales Manager and will facilitate sales throughout the region. Discover the POWER of AstaReal® Astaxanthin! “NOVASTA® Astaxanthin at a glance: • One of the nature’s most powerful antioxidants • Pure algal flour, derived from microalgae Haematococcus pluvialis • NOVASTA® is available in two different forms: 4.5-5% biomass (NOVASTA® biomass) and 1.5% encapsulated powder (NOVASTA® EB15) • Classified as feed raw material, produced in- doors, and approved by the Swedish Board of Agriculture • Can be added to a wide array of feed applications • Suitable for all animals, including pets and animals in competitive sports, agriculture, and aquaculture • Supports animal wellbeing, fitness, and general health, with proven benefits for muscles, eyes, brain, immune system, fertility, and stress resistance (e.g. heat stress)” Let our astaxanthin expertise work for you and get in touch with us. www.astareal.se | [email protected] The Trusted Leader in Natural Astaxanthin Production, R&D and Clinical Science. We truly believe that: ”What benefits my body can benefit my companion animal!”

NEWS 14 FEED & ADDITIVE MAGAZINE June 2022 Selko, the feed additive brand of Trouw Nutrition, recently held a webinar on managing grain quality and optimizing grain investment amid ongoing geopolitical problems and disruptions of grain supplies. Here are the outtakes from the webinar: With Russia and Ukraine generating about 30% of the world’s traded wheat crop, it is unclear how much the geo-political conflict will affect production and grain prices. Higher energy prices also may affect parts of the feed production process including grain drying. Market uncertainty has prompted changes in grain production around the globe. Australia and India have expanded wheat crops and the U.S. plans for a larger corn crop. Meanwhile, an ongoing drought in Brazil and Argentina is expected to lower yields. Global corn production is anticipated to be predominantly from the U.S. and Brazil. Ukraine’s harvest is expected to Trouw Nutrition, Selko share insights on managing grain quality in 2022 Young scientists explore threats posed by mycotoxins More than 50 university students and young professionals, along with “young at heart” academics, consultants and industry professionals, convened for the inaugural Young Scientist Forum on 19 May, following the World Mycotoxin Forum in Parma, Italy. The event was hosted by Trouw Nutrition, Nutreco’s livestock feed business. Feedback from participants will help inform and steer future areas of mycotoxin research. During the forum, participants explored the health and performance challenges caused by mycotoxins, and the discussion placed a special emphasis on the socioeconomic consequences that mycotoxin contamination inflicts on low-income households. The aflatoxin M1 challenge affecting producers in Africa is a good example of mycotoxins’ devastating effects. Climate change was also part of the conversation, as weather and temperature conditions can increase the growth of mycotoxigenic fungi and lead to multiple mycotoxins synthesis. As participants discussed the complexity of today’s mycotoxin environment, it became very evident that management strategies rooted in a single mode of action – such as mycotoxin binding – cannot deliver sufficient protection. Integrated approaches based on multiple modes of action, including binding, gut health support and immune modulation can deliver a more effective approach to management and mitigation efforts. Dr. Swamy Haladi, Global Programme Manager Mycotoxin Risk Management at Trouw Nutrition, noted the importance of engaging the ideas of students and young professionals. “In each generation, young minds always come up with out of the box and innovative ideas and they understand the challenges and the expectations of the ever-evolving consumer segment,” Dr. Haladi said. University students and young professionals discussed socioeconomic, environmental and health threats posed by mycotoxins during the inaugural Young Scientist Forum hosted by Trouw Nutrition, following the World Mycotoxin Forum in Italy.

NEWS FEED & ADDITIVE MAGAZINE June 2022 15 be down by at least 50%. Wheat producing regions outside of Ukraine and Russia are expanding production. With so many disruptions, the feed production sector should anticipate the potential for lower quality grain supplies and consider interventions to help safeguard grain quality. Moulds that generate mycotoxins are an ongoing concern for grain quality. Moulds can threaten crops in the field, during transport or in storage. Damaged kernels or broken grains can host moulds while oxygen levels, temperature, relative humidity, pH, and water activity can all increase mould growth rate. Managing water activity is an area of focus for defending against moulds in grains. For several years, the pet food industry has evaluated how even low water activity levels can affect mould growth. About 80% of agricultural commodities are infected with mycotoxins and the problematic effects of mycotoxins can make some grain unusable in feed. Looking just at the reductions in stored grain, losses during storage as well as mycotoxin contamination can be more than 30%. Mould growth results in a noticeable difference in the nutritional quality of corn including a drop in metabolic energy, crude protein and fat content. To guard against mould’s adverse effects, contamination prevention efforts should start in the field and continue through transport, storage and production. In the field, weather, drought, harvest rains, pests and mould growth can harm quality. Scoring systems created by the USDA are a helpful tool for evaluating quality factors including grade, moisture, nutritional profile, physical quality and mycotoxin presence. Scoring systems are available for corn and other grains and oilseeds. In storage, temperature shifts can allow condensation build-up and conditions for moisture to pool on stored grain. Grains and oilseeds can be contaminated with mycotoxins during transport or at the feed mill where moulds are typically present in screw conveyors, ingredient bins, elevator legs, pellet mill coolers, feed bins and trucks. Kemin Industries opened a new 36,000-square-foot office and a distribution center to enhance Mexico and Central America operations. Kemin Industries opens new facilities in Mexico Kemin Industries opened new offices and a distribution center in Mexico based in Guadalajara, Jalisco. For nearly 30 years, Kemin has been growing its business within Mexico and Central America and this new location will offer improved service and solutions to better serve its customers. A ribbon-cutting ceremony was held Tuesday, May 17, which included Kemin's worldwide executive team and members of the Nelson family who founded Kemin in 1961, Libby Nelson and Kimberly Nelson. The new state-of-the-art, 36,000-square-foot building has 5,800 square feet of office space that can accommodate up to 40 team members and includes conference rooms that will allow Kemin customers, stakeholders, and partners to collaborate at the facility. The new product distribution warehouse can hold more than 1,000 metric tonnes of product and features a dedicated Kemin Application Solutions (KAS) area to build, pilot, and demonstrate customer-tailored systems for optimal product application. To help support the growth in Mexico, Kemin made strategic shifts in their leadership team. In addition to Romero and Garcia, Kemin has promoted Gloria Noriega to Senior Regulatory Affairs Manager for Mexico and Central America. Noriega serves as the official government liaison for the country's regulatory authority and represents Kemin as part of the company's membership with CONAFAB.

NEWS 16 FEED & ADDITIVE MAGAZINE June 2022 Cloudfarms, SUISAG launch app to track pigs Together with SUISAG, the service partner for Swiss pig producers and international genetics customers, Cloudfarms introduced an innovative application of its existing production management system to pig producers. The “Pig Passport” enables breeding farms, production farms and processors to register and analyze production data of each individual pig from birth to processing. The registered production data contains information such as the pig's genetic pedigree, feed consumption, or health information. An electronic ear tag connected to the Cloudfarms Mobile App allows fast, reliable, and easy data entry for each pig directly in the barn. The individual animal data are made available in real-time reports through the Cloudfarms web application. In cooperation with SUISAG first pig producers from Switzerland and Germany have started to test the innovative software application in their daily operations. Thereby, the Cloudfarms Mobile App is integrated into SuisDataManager, the existing reporting solution from SUISAG, which is widely used by pig producers in Switzerland. As part of the test phase, the software application will be further customized to the pig producers’ specific needs. In a next step, SUISAG will make the Cloudfarms Mobile App together with the SuisDataManager available to all interested pig producers in Switzerland and Germany. Avivagen Inc., a life sciences corporation focused on developing and commercializing products for livestock, companion animal and human applications that safely enhances feed intake and supports immune function, thereby supporting general health and performance, is pleased to announce that Avivagen’s oxidized carotenoid-based feed additive product has received approval for use in China. “Core to our success to date has been the strong inroads we’ve made across key Asian feed markets, and we’re thrilled to now have regulatory approval to bring OxC-betaTM to feed producers and commercial operations across China,” says Kym Anthony, Chief Executive Officer, Avivagen. “Having direct access to the world’s largest feed market at a time of continued growth has the potential to be transformative for Avivagen and help drive greater adoption and growth in Asia and worldwide. The approval comes as a result of Avivagen working closely with COFCO Biotech, a state-owned multi-billion-dollar company, and follows successful trials across numerous species. Avivagen announces approval in China Avivagen Inc. announced that OxC-betaTM, its oxidized carotenoid-based feed additive product has received approval for use in China. Cloudfarms, a subsidiary of BASF Group, cooperated with SUISAG to launch “Pig Passport”, an innovative application enabling individual tracking of pigs from birth to processing.


NEWS 18 FEED & ADDITIVE MAGAZINE June 2022 Poultry industry reps gather together at Biochem's event in Turkey Biochem, one of the global players of the animal nutrition and feed additives industry, hosted representatives of the poultry industry from India, Middle East and Africa (IMEA) region in Istanbul. Industry representatives, who gathered at Crowne Plaza Istanbul Florya Hotel on 18-19 May 2022, had the opportunity to refresh their knowledge at the event entitled "Challenges in poultry production: Outlook on current and future industry trends and solutions". Biochem Zusatzstoffe Handels- und Produktionsgesellschaft mbH, one of the leading players in the animal nutrition and feed additives industry in the world, held its biggest regional event in Istanbul on 18-19 May 2022. Nearly 150 "poultry industry" representatives from 25 countries in India, Middle East and Africa (IMEA) region attended the event entitled "Challenges in poultry production: Outlook on current and future industry trends and solutions". The event, which was held face-to-face in order to reunite with industry representatives in different regions after the pandemic and to strengthen communication and interaction, witnessed a remarkable participation. The event, where many topics related to the poultry industry were discussed, started with the "Welcome" speech of IMEA Regional Director Uğur Kümbet on May 18. Following Kümbet's speech, Dr. Alexander Grafe, one of Biochem's general managers, made a presentation entitled "Global Challenges". Dr. Grafe touched upon the most important agenda items in recent years that have heavily affected the animal nutrition industry, from

NEWS FEED & ADDITIVE MAGAZINE June 2022 19 the pandemic to the Russia-Ukraine war, from raw material supply problems to prices, and from animal diseases to consumer expectations. Prof. Tayfun Carli from Bursa Uludağ University Veterinary Faculty Microbiology Department, one of the keynote speakers of the event, discussed poultry intestinal microbiome, immunity, and health issues in his presentation. THE EVENT ATTRACTED ATTENTION WITH ITS REMARKABLE CONTENT During the two-day event, Dr. Lydia Zeibich, Biochem Product Manager for Probiotics, attended with two presentations entitled “Probiotics: Key players in gut health and animal production” and “Gut health supports performance”. Dr. Zeibich focused on gut health, a critical issue for the success of poultry farming in her presentation. Melanie Frisch, Biochem IMEA Regional Technical Manager, also drew attention to the issue of wheezing and respiratory distress, which is a symptom of disease in poultry farming, with her presentation entitled “Focus on respiratory health”. Frisch also attracted great attention with her presentations on "High feed prices" and "Quality of raw materials and alternative protein sources", which are essential for the productivity of the enterprises. Dr. Susanne Rothstein, Biochem Product Manager for Trace Minerals, focused on poultry performance with her presentation on “Oxidative stress and organic trace minerals”. With her presentation entitled “Are insects an alternative for animal production?”; she talked about alternative protein sources, one of the most interesting topics of our time. The 2-day event, which drew attention with its intense content and high participation, ended with the "Conclusion and Discussion" section directed by Regional Director Kümbet. Anitox launches Fortrol®, cost-effective Salmonella control for feed U.S.-based feed biosecurity specialist Anitox has unveiled Fortrol®, its new highly cost-effective feed additive to help producers meet feed microbial quality goals. Formulated to control Salmonella in feed ingredients and finished feed, Fortrol® gives producers greater flexibility to respond to incoming feed microbial challenge in mills and processing and deliver safe, effective, affordable rations. “Fortrol® is built on more than 40-years of Anitox feed biosecurity expertise. When applied to finished feed and/or feed ingredients, it reduces risk of pathogen transmission via feed and postheat recontamination. As a preventative and corrective solution, Fortrol® can be used as a flush treatment to mitigate pathogen colonization within feed ingredient processing plants and feed mills. It is with great pleasure that we are introducing Fortrol® in the European market. This launch reinforces our feed pathogen control portfolio and expands Anitox support to our customers in producing safe feed in an efficient way,” explains EMEA Director of Sales Jorge Trindade. “Fortrol® demonstrates highly effective control of Salmonella at risk-dependent variable inclusion rates from 2 to 8 kg/MT. It’s applied using best-in-class Anitox engineering solutions, giving producers the flexibility to switch between Fortrol® and our patented high-performance feed sanitizer Finio®. That puts Anitox in the unique position of being able to offer new cost-effective feed safety programs that address seasonal and formulation-specific risks, as well as critical production needs such as reduced dwell times and continuous recontamination protection,” highlights Director of Nutrition and Live Production Dr. Enrique Montiel.

NEWS 20 FEED & ADDITIVE MAGAZINE June 2022 BIPEA offers new proficiency test in the field of feed Bureau Interprofessionnel d'Etudes Analytiques (BIPEA) has created a new Proficiency Testing Schemes (PTS 107) dedicated to drugs testing. This quality control test is composed of one round and allows laboratories to analyse drugs in feed. A sample of 250 grams of compound animal feed contaminated with antibiotics and coccidiostats will be sent to the participants. When performing analysis on samples, participating laboratories are required to apply their routine methods. For now, 15 registered laboratories from 10 countries apply this new PTS 107 and the required time for analysis is 4 weeks. Proficiency testing programs allow the comparison of several laboratories’ results, in order to evaluate their analytical performance on the same homogeneous sample. These tests are part of the laboratory quality approach and are organized according to ISO / IEC 17043: “General requirements for proficiency testing” requirements. BIPEA has unveiled a new proficiency test in the field of feed. The new quality control test, Proficiency Testing Schemes (PTS 107), is composed of one round and allows laboratories to analyse drugs in compound animal feed. Blue Ocean Barns announced that the California Department of Food and Agriculture (CDFA) has authorized commercial use of the company's seaweedbased supplement as a digestive aid for cattle. Hawaii-based Blue Ocean Barns received authorization from the California Department of Food and Agriculture (CDFA) for commercial use of Brominata, the company's seaweed-based supplement. The decision followed a highly successful trial at Straus Organic Dairy Farm in Marin County, the largest and longest yet conducted with seaweed and dairy cows. CDFA's Safe Animal Feed Education Program provided technical assistance, feed sampling, and analysis during the trial. Brominata is a variety of red seaweed proven in published scientific trials to promote higher energy yield from the digestion of hay and grasses and to reduce cows' methane emissions by 80% or more. The livestock industry has long needed a feed additive to reduce the wasted energy that cattle naturally burp into the atmosphere. Over the past four years, multiple studies by major universities have shown that the supplement is safe for cows and doesn't change the chemistry or taste of milk or meat. CDFA issued a "No Objections Letter" and granted provisional certificates of registration for both the certified organic and nonorganic formulations of Brominata, approving both labels under the state's Livestock Drug Program. Blue Ocean Barns Brominata approved for sale in California

NEWS FEED & ADDITIVE MAGAZINE June 2022 21 INTRODUCING HIGHEST CHOLINE CONCENTRATION IN THE INDUSTRY 1, 3 Zenobi et al., J Dairy Sci. 101:1088 (2018) 2 Lima et al., The Veterinary Journal. 193:140-145 (2012). All trademarks are property of Balchem Corporation © 2021 Balchem Corporation. Balchem Italia Srl Via del Porto Snc 28040 Marano Ticino (NO) Italy Telephone +39 0321 9791 Fax +39 0321 979249 E-mail [email protected] Website BalchemANH.com To learn more, contact your local Balchem representative or distributor. Combining advanced core design with industry- leading encapsulation technology, Balchem delivers the most unique rumen-protected choline product on the market today. • Most researched base choline product in the industry • Highest payload while eliminating the need for a carrier • Durable and feed stable • Reduced carbon footprint • Non-GMO • European manufacturing Highest Choline Concentration in the Industry The ReaShure line is proven to deliver results throughout an animal’s life. • 2,10 kg of milk per day improvement, or 640,50 kg more milk over the full lactation.1 • Proven reduction in metabolic disorders including ketosis, displaced abomasum and subclinical milk fever.2 • In utero impact on the calf, leading to growth and health improvements.3 Advanced Technology, Proven Results


ISSUE FOCUS FEED & ADDITIVE MAGAZINE June 2022 23 Animal science turns to advancing resilience for heat tolerance Dr. Gwendolyn Jones ADM - Pancosma Expert Chat – Managing heat stress, and a research postcard from down under Dr. Narendra Venkatareddy Selko Feed Additives - Trouw Nutrition Reducing heat stress impact to improve broilers’ performance and welfare Dr. Ruth Raspoet & Lin Wang Phileo by Lesaffre Preparing poultry for heatwaves Paulina Abramowicz-Pindor, PhD AdiFeed Co Ltd. Understanding heat stress in dairy to alleviate it Delphine Lacombe Delacon Biotechnik GmbH Heat stress management: The importance of beef cattle nutrition Bruno Martin Lallemand Animal Nutrition

ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE June 2022 "Birds cannot sweat and must rely on panting to cool down. That’s an inefficient method when you consider their feathers also serve as insulation. Maintaining animal welfare becomes harder during high-heat conditions. Additionally, the drop in performance and egg production can mean economic challenges for producers’ businesses. Producers should take a holistic approach of feed, farm and health management to defend against heat stress." As global temperatures increase, heat stress is becoming a major challenge for poultry producers globally. Since 1980 every decade has seen a temperature hike, and the seven hottest years on record occurred since 2015.1 Different strategies of management practices and diet-based interventions can support flocks during episodic or sustained periods of high temperatures. We caught up with Dr. Narendra Venkatareddy, global product manager with Selko, the Feed Additives brand of Nutreco, to learn more about how heat stress challenges affects poultry flocks – and what producers can do to manage heat stress. He also shared findings from a trial conducted in Australia with the University of New England. The trial found that the type of trace mineral supplied to laying hens can influence quality and performance indicators including egg production, egg FCR (feed conversion ratio) and egg mass. Where are you seeing heat stress becoming more of a problem for poultry producers? Global climate changes have their effect on animal production. Where heat stress used to be an issue for certain regions only, nowadays also areas with moderate climates are affected. The number of days where the temperature-humidity index (THI) exceeds the comfort threshold of the animals is increasing in the northern United States, Canada, and Europe and thus heat stress has become one of the most important ambient stressors in animal production worldwide. What consequences does heat stress present to poultry? Birds cannot sweat and must rely on panting to cool down. That’s an inefficient method when you consider their feathers also serve as insulation. Maintaining animal welfare becomes harder during high-heat conditions. Additionally, the drop in performance and egg production can mean economic challenges for producers’ businesses. For example, in just one country – the U.S. - industry research shows that heat stress causes the nation’s producers about $128 to $165 million in economic losses annually.2 Expert Chat MANAGING HEAT STRESS, AND A RESEARCH POSTCARD FROM DOWN UNDER Dr. Narendra Venkatareddy Global Product Manager Selko Feed Additives - Trouw Nutrition

ISSUE FOCUS FEED & ADDITIVE MAGAZINE June 2022 25 What are some signs that indicate birds are experiencing heat stress? The list is extensive. Clinical symptoms can include panting, lethargy, lower feed intake, poor average daily gain, higher feed conversion ratios and a drop in production or performance. In layers, high temperatures can correspond to a noticeable decline in daily egg production and the situation may adversely influence elements like egg mass and shell quality. How can high heat conditions affect a bird internally? The negative effects of heat stress, such as generation of free radicals, antioxidant imbalance, intestinal hypoxia, and gut barrier integrity disruption happen prior to the occurrence of clinical symptoms (e.g. panting, drooling, reduced feed intake) (Varasteh et al., 2017). Therefore, it is of crucial importance to have preventive strategies in place before heat stress is expected to occur. Traditional strategies to manage harmful effects of heat stress have focused on reducing oxidative stress alone. Birds can develop “leaky gut” or internal damage to the intestinal track allowing for easier movement of pathogens and hampering immune system function. They also can generate larger amounts of cellular-damage-causing free radicals and may see increased blood pH, which can lead to electrolyte imbalances. However, with the more recently uncovered mechanisms suggesting a direct effect on the GIT in mind, new heat stress strategies have a twofold approach: reducing oxidative stress and supporting gut health. Gut health can be supported through Betaine, high level copper and organic acid products especially during heat stress conditions. What management practices can help prevent or mitigate heat stress? Producers should take a holistic approach of feed, farm and health management to defend against heat stress. The general management practices include reducing bird density, feeding during cooler parts of the day, reducing dietary protein levels, and adjusting nutritional density, or covering water tanks and flushing warm water out of a system to provide colder drinking water. But not all of these options may make sense based on the cost or infrastructure investment. For example, refrigerated water can be challenging to supply to birds in some regions. Also, some production environments traditionally have open houses, which